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. Author manuscript; available in PMC: 2010 Apr 12.
Published in final edited form as: J Cereb Blood Flow Metab. 2006 Nov 1;27(5):909–918. doi: 10.1038/sj.jcbfm.9600419

Table 2.

Clearance rates of 125I-labeled Aβ, apoE and apoJ across the BBB and via the ISF flow.

Clearance rates (pmol/min/g ISF)
125I-labeled
molecules		 Transport via BBB Transport via ISF
A β 40 0.214 ± 0.020 0.030 ± 0.001
A β 42 0.101 ± 0.014 0.029 ± 0.001
non-lip-apoE3 0.036 ± 0.003 0.028 ± 0.002
lip-apoE3 non-detectable 0.035 ± 0.004
apoJ 0.155 ± 0.009 0.033 ± 0.004
Aβ42-apoJ 0.185 ± 0.009 * 0.031 ± 0.003

Values were calculated with eqs. 2,4, and 5; Mean ± s.e.m. from 6-8 mice per test molecule.

*

p<0.01, Aβ42-apoJ compared to Aβ42. Non-lip-apoE3, lipid-poor apoE3; lip-apoE3, lipidated apoE3.