Table 2.

Renal Function

	No Aprotinin	LD	SF	DF	F-test	P-value
Serum Cr (mg/dL)
Baseline	0.8 ± 0.2	0.9 ± 0.3	0.8 ± 0.2	0.9 ± 0.3	1.49	0.23
POD1	1.0 ± 0.4	1.1 ± 0.4	1.1 ± 0.6	1.0 ± 0.2	0.54	0.66
POD4	0.7 ± 0.1	0.8 ± 0.2	0.6 ± 0.1	0.7 ± 0.1	1.52	0.24
BUN (mg/dL)
Baseline	9.7 ± 3.0	10.0 ± 4.5	8.5 ± 2.7	9.3 ± 4.2	0.54	0.66
POD1	28.1 ± 10.8	29.0 ± 10.1	26.9 ± 13.2	23.6 ± 6.4	0.90	0.45
POD4	12.7 ± 7.2	10.4 ± 3.7	16.8 ± 6.0	12.6 ± 2.7	1.39	0.28
Urine Protein (mg/dL)
Baseline	7.6 ± 3.2	14.3 ± 10.0	10.0 ± 5.9	13.0 ± 12.0	0.68	0.58
POD1	7.2 ± 3.9	10.2 ± 10.2	6.0 ± 0.0	6.3 ± 0.8	0.72	0.55
POD4	46.2 ± 13.3	72.8 ± 54.6	38.8 ± 16.4	54.2 ± 39.7	0.85	0.48
Urine Protein/Cr
Baseline	1.4 ± 1.9	0.5 ± 0.1	0.6 ± 0.3	1.1 ± 1.1	0.74	0.54
POD1	0.3 ± 0.2	0.2 ± 0.1	0.2 ± 0.1	0.1 ± 0.1	1.47	0.26
POD4	0.5 ± 0.4	0.4 ± 0.2	0.5 ± 0.2	0.6 ± 0.6	0.27	0.85

LD; Low dose, SF; Standard full dose, DF; Double full dose

Cr; serum creatinine, BUN; blood urea nitrogen, POD; Postoperative day