Table 1.

Established Common Breast-Cancer Susceptibility SNPs proven to affect miRNA binding.

SNP	Gene	Location	Chromosome	Population	No. of cases/controls	Ref	Notes	Genotype and BC risk	Odds Ratio (95% CI; p)
rs1982073 (T+29C)	TGFB1	Exonic (missense; Leu10Pro)	19(q13.2)	European (Netherlands)	143/3,646	[27]		CC-carriers have increased risk of BC	1.4 (1.1–2.0; p=0.04)
				European	3,987/3,867	[28]	TGFB1 Pro variant is more highly secreted by cells	CC vs T-carriers (Pro/Pro vs Leu-carriers) have increased BC risk	1.21 (1.05–1.37; p= 0.01)
rs1799782 (580C>T)	XRCC1	Exonic (missense; Arg194Trp)	19(q13.31)	Mixed ethnicity (Meta-analysis)	4,933/6,775	[22]	Breast cancer together with other cancers	TT+CT vs CC-carriers (Trp/Trp+Arg/Trp vs Arg/Arg-carriers) have lower BC risk	0.89 (0.81–0.98)
				Mixed ethnicity (Nurses’ Health Study)	1,004/1,385	[35]	Association with Breast cancer risk and carotenoids levels	Trp-carriers have a marginal lower risk of BC and a definitely lower risk in association with high carotenoids levels	0.79(0.60–1.04) alone and 0.32 (0.16–0.61; p=0.003) with high carotenoids levels
				American	502/502	[36]	Postmenopausal women	Trp-carriers among postmenopausal women have lower BC risk	0.62 (0.40–0.95; p<0.05)