Table 2.

List of target SNPs inside cancer-relevant genes analyzed by direct sequencing in breast cancer and control samples together with an example of interacting miRNA.

GENE	SNP	Allelic Variants	Genomic Position	INTERACTING miR	Active Allele	MFE	MFE change
BRCA1	rs799917	C/T	exonic	miR-638^,#	C	−27.52	−8%
MDM2	rs769412	A/G	exonic	miR-296-5p	G	−18.15	66%
TGFBR1	rs334348	A/G	3′UTR	miR-628-5p^,#	G	−20.95	29%
TP53BP2	rs17739	C/T	3′UTR	miR-129-5p	T	−19.31	121%
TP53INP1	rs7760	G/T	3′UTR	miR-330-5p	G	−17.92	−92%
XIAP	rs28382751	A/C	3′UTR	miR-542-5p^	C	−21.25	28%

For each target SNP, an example of computational prediction of MFE percentage change with a selected miRNA is shown.

^{^}SNP::miR interactions tested by luciferase assay (Fig 3a and Supplemental Fig 3), and

^#SNP::miR interactions tested by Western blot (Fig. 3b).