Table 3.
Target SNP association with disease status.
| SNP (gene) | (SPORADIC+FAMILIAR) vs CONTROL | FAMILIAR vs CONTROL | SPORADIC vs CONTROL | FAMILIAR vs SPORADIC | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI)* | p value | OR (95% CI)* | p value | OR (95% CI)* | p value | OR (95% CI)* | p value | ||
| rs334348 (TGFBR1) | AG vs AA | 1.69 (1.01, 2.83) | 0.048 |
2.2 (1.29, 4.07) 2.67 (1.19, 6.03) |
0.005 0.002 |
1.15 (0.63, 2.11) | 0.65 |
1.99 (1.15, 3.46) 2.17 (1.15, 4.07) |
0.01 0.02 |
| GG vs AA | 0.71 (0.26, 1.99) | 0.52 | 0.46 (0.11, 1.86) | 0.27 | 0.94 (0.31, 2.88) | 0.92 | 0.48 (0.12, 1.97) | 0.31 | |
| rs799917 (BRCA1) | CT vs CC |
1.57 (1.04, 2.37) 1.86 (1.01, 3.42) |
0.03 0.046 |
1.25 (0.76, 2.05) | 0.38 | 1.98 (1.20, 3.26) | 0.007 | 0.63 (0.36, 1.10) | 0.1 |
| TT vs CC | 1.95 (1.06, 3.6) | 0.03 | 1.26 (0.59, 2.71) | 0.55 | 2.81 (1.40, 5.64) | 0.003 | 0.45 (0.21, 0.97) | 0.04 | |
*
Odds Ratio according to univariate and to multivariate (adjusted for age) logistic regression model, first and second row respectively. Only OR from statistically significant multivariate logistic regressions are shown.