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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: Bioorg Med Chem. 2009 Apr 12;17(10):3536–3542. doi: 10.1016/j.bmc.2009.04.011

Figure 6.

Figure 6

Time dependent loss of enzymatic activity. Percent remaining activity versus time plot obtained by incubating inhibitor 16 (37 µM) with human neutrophil elastase (700 nM) in 0.1 M HEPES buffer containing 0.5 M NaCI, pH 7.25, and 1% DMSO. Aliquots were withdrawn at different time intervals and assayed for enzymatic activity using MeOSuc-AAPV p-NA by monitoring the absorbance at 410 nm.