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. Author manuscript; available in PMC: 2010 Jul 23.
Published in final edited form as: J Med Chem. 2009 Jul 23;52(14):4277–4287. doi: 10.1021/jm900106f

Table 3.

The IC50 (µM) and 95% confidence intervals (in parenthesis) of selected compounds for inhibiting transcriptional activation by exogenous human Gli1 or ΔNGli229 in C3H10T1/2 cells 24 h after addition of the test compound (Figure 8).

Gli1 Gli2
36 11.4 (7.5 – 17.5) 35.2 (17.8 – 59.9)
50 11.4 (7.9 – 16.3) 29.4 (2.9 – 66.6)
63 6.9 (6.1 – 7.8) 23.9 (12.3 – 49.0)
65 9.4 (6.40 – 15.4) 20.5 (9.2 – 30.9)