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Hypothesized model of the relationships among progesterone/progesterone receptor (P4/PGR), prostaglandins (PGs), oxytocin (OT), and ADAMTS proteases in bovine periovulatory follicles, based on data discussed in the manuscript. Positive effects and potential intra-follicular positive feedback loops are indicated by “+”, whereas “+/−” indicates that the effect varies depending on the putative regulator, ADAMTS subtype, and follicular cell type.
