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. Author manuscript; available in PMC: 2010 Apr 12.
Published in final edited form as: Anim Reprod. 2009 Jan;6(1):60–71.

Table 1.

Summary of results of experiments to determine if P4/PGR and/or PGs mediate the effects of the LH/FSH surge on levels of mRNA for ADAMTS1 and 91.

Granulosa Cells Theca Cells
P4/PR2 PGs3 P4/PR2 PGF2α4 PGE24
ADAMTS1 − + + + +
ADAMTS9 + NC + NC +
1

Granulosa and theca cells were isolated from preovulatory follicles 36 h after a luteolytic dose of PGF2α and cultured for 12, 24, 36, and 48 h. “+”, results indicate that the hormone (P4 or PG) has a positive effect on levels of the mRNA, mimicking the effects of gonadotropins; “−”, results indicate an effect that did not mimic that of the gonadotropin; NC, results show no effect.

2

Granulosa or theca cells were cultured with LH (100 ng/ml), LH + mifepristone (PGR inhibitor), or LH + mifepristone + MPA (synthetic progestin).

3

Granulosa cells were cultured with LH (100 ng/ml) + graded doses of the COX-2 inhibitor NS398 (0.01, 0.1, and 1 μM).

4

Theca cells were cultured with PGE2 or PGF2α (1 μM).