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A). Representative image of the medial tibial plateau of a menisectomised (MNX) animal at 35 days post surgery showing full thickness cartilage fibrillation and proteoglycan loss (arrows). A large osteophyte (circled) has formed at the joint margin. B). Representative image of the medial tibial plateau of a sham (SHAM) operated animal at 35 days. There is no evidence of proteoglycan loss or fibrillation of the cartilage surface. The joint margin appears normal. Scale bars 100 μm.
