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The effect of increasing doses of a MMP inhibitor, in the rat MNX model of OA, on chondropathy (Panel A), osteophytosis (Panel B) and the number of vessels crossing the osteochondral junction (Panel C). Treatment with 0.5 and 2.5 mg bid resulted in significant decreases in the chondropathy scores (P < 0.05) and in the number of blood vessels crossing the osteochondral junction (P < 0.001).There was no significant effect on osteophytosis.
