Fig. 4.

Time course showing the effect of increasing doses of a MMP inhibitor on pain behavior, as measured by a difference in weight bearing, in the MNX and SHAM animals. Vehicle-treated animals continued to show pain behavior but this behavior was dose-dependently decreased by increasing doses of M503092. SHAM animals returned to normal weight bearing over the course of the experiment. Values for 0.125 mg/kg/bid and 2.5 mg/kg/bid have been offset by 0.5 days to increase the clarity of presentation by preventing overlap of error bars. Areas under the curve were calculated for the 10 individual animals in each treatment group and a mean with 95% CI's computed. Differences between groups were sought with 1-way ANOVA with Bonferroni corrections.