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. 2010 Mar 9;102(7):1163–1173. doi: 10.1038/sj.bjc.6605571

Table 2. Spearman's correlation between markers and clinicopathological parameters.

P EGFR P-EGFR Her2 P-Her2 ERBB3 PTEN P-PTEN P65 P-p65 P65 nucl PI3K CLUSTER
LN                        
 Correlation coefficient 0.013 0 0.091 −0.04 −0.014 −0.118 −0.411 −0.096 −0.132 0.238 −0.177 −0.128
 P 0.919 1 0.477 0.757 0.914 0.355 0.001 0.453 0.301 0.06 0.166 0.319
                         
Metastasis                        
 Correlation coefficient 0.271 −0.042 0.144 −0.122 0.074 0.127 −0.122 0.208 0.118 0.171 −0.031 0.075
 P 0.032 0.747 0.259 0.341 0.564 0.322 0.341 0.103 0.357 0.179 0.808 0.559
 N 63 63 63 63 63 63 63 63 63 63 63 63
                         
PSA                        
 Correlation coefficient 0.131 0.032 0.059 0.113 −0.041 −0.294 −0.042 −0.137 −0.142 0.179 −0.135 0.198
 P 0.316 0.805 0.652 0.384 0.756 0.022 0.748 0.292 0.275 0.168 0.3 0.126
                         
Age                        
 Correlation coefficient 0.008 −0.033 0.055 0.054 0.079 −0.153 −0.13 −0.069 −0.236 −0.154 0.11 0.098
 P 0.951 0.795 0.671 0.676 0.538 0.231 0.311 0.593 0.062 0.229 0.39 0.445
                         
Gleason                        
 Correlation coefficient −0.008 0.042 −0.17 0.05 −0.076 −0.09 −0.286 −0.166 0.044 0.281 −0.092 −0.116
 P 0.95 0.746 0.183 0.696 0.555 0.484 0.023 0.194 0.733 0.026 0.474 0.367
                         
Invasion                        
 Correlation coefficient 0.121 0.318 −0.178 0.392 0.225 −0.152 0.038 −0.122 −0.174 0.304 −0.026 0.022
 P 0.344 0.011 0.163 0.002 0.076 0.235 0.767 0.34 0.173 0.015 0.837 0.867
                         
Margin                        
 Correlation coefficient 0.238 0.382 −0.05 0.5 0.215 −0.051 0.045 −0.09 −0.149 0.374 −0.188 0.1
 P 0.061 0.002 0.699 0 0.09 0.69 0.724 0.484 0.243 0.003 0.14 0.435
                         
Stage                        
 Correlation coefficient 0.214 0.315 −0.071 0.359 0.219 −0.002 −0.032 −0.09 −0.097 0.319 −0.125 0.05
 P 0.092 0.012 0.579 0.004 0.084 0.987 0.803 0.483 0.449 0.011 0.329 0.699
                         
Grade                        
 Correlation coefficient −0.037 0.012 −0.196 0.014 −0.12 −0.11 −0.307 −0.192 0.084 0.311 −0.06 −0.117
 P 0.771 0.925 0.123 0.915 0.348 0.391 0.014 0.132 0.512 0.013 0.639 0.361
                         
Infiltra                        
 Correlation coefficient 0.195 0.192 0.091 0.238 0.084 −0.026 −0.04 −0.096 0.053 0.134 −0.082 0.079
 P 0.126 0.131 0.477 0.06 0.515 0.838 0.757 0.453 0.68 0.295 0.525 0.54
                         
BPH                        
 Correlation coefficient −0.162 −0.046 −0.123 0.061 −0.144 −0.177 −0.005 −0.252 −0.072 0.101 −0.018 −0.013
 P 0.204 0.721 0.336 0.635 0.261 0.166 0.967 0.046 0.577 0.433 0.886 0.92
                         
Death                        
 Correlation coefficient 0.195 0 0.091 −0.132 0.084 0.066 −0.318 0.096 −0.04 0.238 0.014 −0.012
 P 0.126 1 0.477 0.301 0.515 0.608 0.011 0.453 0.757 0.06 0.916 0.928
                         
Recurrence                        
 Correlation coefficient 0.359 0.272 0 0.281 0.236 −0.074 0.084 0.068 0.019 0.305 −0.163 0.198
 P 0.004 0.031 1 0.026 0.062 0.562 0.511 0.596 0.884 0.015 0.201 0.12

Abbreviations: LN=lymph node infiltration; PSA=prostate-specific antigen before surgery; Invasion=extra-capsular invasion; margin=surgical margin; Infiltration=peri-neural infiltration; BPH=benign hyperplasia; BCR=biochemical recurrence; p65 Cyto=cytoplasmic staining of p65; p65 nuc= nuclear p65 staining; Cluster=cluster of non-supervised hierarchical analysis (combination of marker allowing clustering of patients in five groups); Rho=Spearman's coefficient correlation.

Significant correlations (P<0.05) are indicated by bold numbers.