Table 3. Results of the multivariable Cox's PH model (N=269).

Variables	HR (95% CI)a	P-value for test of no association	P-value for test of PH	P-value for test of linearity
Stage: (IIIB+pleural effusion/4 vs IIIA/IIIB)	1.815 (1.268, 2.597)	0.001	0.204	N/A
ECOGb performance status: (2 vs 0-1)	1.348 (0.958, 1.896)	0.086	0.165	N/A
Smoking status: (ever vs never)	2.087 (1.349, 3.230)	0.001	0.135	N/A
Chemotherapy type: (single vs double)	1.539 (1.082, 2.188)	0.016	0.067	N/A
Log2 CRP: (per doubling of CRP values)	1.108 (1.027, 1.196)	0.008	0.039	0.130
Albumin: (per ↓c of 1 g l–1)	1.015 (0.974, 1.058)	0.485	<0.001	0.024
Log2 LDH: (per doubling of LDH values)	2.159 (1.700, 2.742)	<0.001	0.636	0.590
Alkaline phosphatase: (per ↑d of 10 U l–1)	1.019 (0.993, 1.047)	0.150	0.075	0.034
Neutrophil counts: (per ↑ of 1 × 109 l–1)	1.082 (1.037, 1.129)	<0.001	0.027	0.041
Lymphocytes: (per ↓ of 1 × 109 l–1)	1.307 (1.050, 1.626)	0.016	0.550	0.460
Deviancee	1902.2
AIC	1922.2

Abbreviations: AIC=Akaike's information criterion; CRP=C-reactive protein; LDH=lactate dehydrogenase; PH=proportional hazard.

N/A: the test of linearity is not applicable to categorical covariates.

^aAdjusted hazard ratio (HR) and 95% confidence interval (95% CI).

^bEastern cooperative oncology group.

^c↓: decrease.

^d↑: increase.

^eDeviance=−2^*log-likelihood.