Table 2. Numbers of cases (Obs), standardised incidence ratio (SIR) and absolute excess risk (AER) per 100 000 person-years of selected second primary cancers after lung cancer by sex and histology.
|
Squamous cell carcinoma
|
Small cell carcinoma
|
Adenocarcinoma excluding bronchioalveolar
|
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cancer sites (ICD 9th revision) | Obs | SIR | 95% CI | AER | Obs | SIR | 95% CI | AER | Obs | SIR | 95% CI | AER |
| Women | PY=34 344 | PY=16 763 | PY=48 929 | |||||||||
| All but non-melanoma skin | 377 | 1.28 | (1.16–1.42) | 242.55 | 149 | 1.16 | (0.98–1.36) | 119.65 | 555 | 1.49 | (1.37–1.62) | 374.30 |
| Smoking-related cancers | 142 | 2.31 | (1.94–2.72) | 234.27 | 58 | 2.28 | (1.73–2.95) | 194.47 | 164 | 2.24 | (1.91–2.61) | 185.80 |
| Head and neck | 31 | 5.69 | (3.87–8.08) | 74.41 | 9 | 3.49 | (1.59–6.63) | 38.31 | 13 | 1.85 | (0.99–3.17) | 12.23 |
| Oesophagus (150) | 14 | 3.31 | (1.81–5.56) | 28.45 | 6 | 3.30 | (1.21–7.18) | 24.95 | 7 | 1.72 | (0.69–3.55) | 6.01 |
| Bladder and kidney | 40 | 2.31 | (1.65–3.14) | 65.95 | 18 | 2.45 | (1.45–3.88) | 63.59 | 69 | 3.32 | (2.58–4.21) | 98.59 |
| Leukaemias (204–208) | 9 | 1.28 | (0.58–2.42) | 5.73 | 9 | 3.06 | (1.40–5.82) | 36.14 | 22 | 2.50 | (1.57–3.79) | 27.00 |
| Other smoking-related cancers | 37 | 1.94 | (1.36–2.67) | 52.14 | 10 | 1.45 | (0.70–2.67) | 18.58 | 41 | 1.93 | (1.38–2.62) | 40.34 |
| Colorectal (153, 154) | 41 | 0.84 | (0.60–1.14) | −22.74 | 14 | 0.67 | (0.36–1.12) | −41.14 | 74 | 1.26 | (0.99–1.58) | 31.21 |
| Colon (153) | 30 | 0.90 | (0.61–1.29) | −9.71 | 9 | 0.63 | (0.29–1.19) | −31.53 | 56 | 1.43 | (1.08–1.86) | 34.42 |
| Rectum (154) | 11 | 0.70 | (0.35–1.24) | −13.73 | 5 | 0.75 | (0.24–1.74) | −9.94 | 18 | 0.93 | (0.55–1.46) | −2.77 |
| Non-smoking-related cancer | 194 | 1.06 | (0.91–1.22) | 31.03 | 77 | 0.93 | (0.74–1.16) | −33.66 | 317 | 1.32 | (1.18–1.47) | 157.14 |
| Female breast (174) | 87 | 1.09 | (0.88–1.35) | 20.92 | 29 | 0.77 | (0.52–1.11) | −51.68 | 135 | 1.25 | (1.05–1.48) | 55.12 |
| Cervix uteri (180) | 11 | 1.31 | (0.65–2.35) | 7.58 | 6 | 1.56 | (0.57–3.41) | 12.85 | 12 | 1.07 | (0.55–1.87) | 1.63 |
| Corpus uteri (182) | 8 | 0.43 | (0.19–0.85) | −30.88 | 3 | 0.36 | (0.07–1.05) | −31.82 | 19 | 0.76 | (0.46–1.18) | −12.52 |
| Ovary (183) | 23 | 1.47 | (0.93–2.21) | 21.41 | 9 | 1.28 | (0.59–2.43) | 11.74 | 28 | 1.37 | (0.91–1.98) | 15.52 |
| Thyroid gland (193) | 6 | 2.48 | (0.91–5.40) | 10.43 | 3 | 2.64 | (0.54–7.71) | 11.12 | 18 | 4.87 | (2.88–7.69) | 29.23 |
| Other non-smoking-related cancers | 59 | 1.01 | (0.76–1.30) | 1.57 | 27 | 1.10 | (0.72–1.60) | 14.12 | 105 | 1.47 | (1.20–1.77) | 68.16 |
| Men | PY=212 428 | PY=34 293 | PY=64 945 | |||||||||
| All but non-melanoma skin | 2882 | 1.21 | (1.16–1.25) | 231.99 | 408 | 1.16 | (1.05–1.27) | 160.26 | 1012 | 1.47 | (1.38–1.56) | 498.00 |
| Smoking-related cancers | 1454 | 1.58 | (1.50–1.66) | 250.63 | 186 | 1.39 | (1.20–1.60) | 151.44 | 428 | 1.73 | (1.57–1.90) | 277.11 |
| Head and neck | 340 | 2.53 | (2.27–2.81) | 96.76 | 33 | 1.50 | (1.04–2.11) | 32.26 | 77 | 2.01 | (1.59–2.51) | 59.57 |
| Oesophagus (150) | 93 | 1.78 | (1.44–2.18) | 19.18 | 12 | 1.46 | (0.75–2.55) | 11.03 | 27 | 1.91 | (1.26–3.09) | 19.76 |
| Bladder and kidney | 565 | 1.87 | (1.72–2.03) | 123.83 | 70 | 1.62 | (1.26–2.04) | 77.98 | 159 | 1.90 | (1.62–2.22) | 116.16 |
| Leukaemias (204–208) | 74 | 0.98 | (0.77–1.23) | −0.71 | 14 | 1.29 | (0.71–2.17) | 9.18 | 33 | 1.58 | (1.09–2.37) | 18.62 |
| Other smoking-related cancers | 382 | 1.07 | (0.96–1.18) | 11.56 | 57 | 1.14 | (0.87–1.48) | 21.01 | 132 | 1.45 | (1.21–1.72) | 62.99 |
| Colorectal (153, 154) | 395 | 1.01 | (0.92–1.12) | 1.84 | 46 | 0.79 | (0.58–1.05) | −35.66 | 129 | 1.15 | (0.96–1.38) | 25.91 |
| Colon (153) | 223 | 1.00 | (0.87–1.14) | 0.00 | 29 | 0.85 | (0.57–1.22) | −14.92 | 81 | 1.24 | (0.98–1.57) | 24.14 |
| Rectum (154) | 172 | 1.04 | (0.89–1.21) | 3.11 | 17 | 0.70 | (0.41–1.13) | −21.25 | 48 | 1.02 | (0.76–1.36) | 1.45 |
| Non-smoking-related cancer | 1033 | 0.96 | (0.90–1.02) | −20.48 | 176 | 1.09 | (1.21–1.58) | 44.48 | 455 | 1.39 | (1.26–1.52) | 195.41 |
| Prostate (185) | 694 | 1.06 | (0.98–1.14) | 18.49 | 111 | 1.19 | (0.98–1.43) | 51.68 | 312 | 1.56 | (1.39–1.79) | 172.37 |
| Testis (186) | 5 | 1.10 | (0.36–2.56) | 0.21 | 1 | 1.26 | (0.03–6.99) | 0.60 | 5 | 3.14 | (1.01–9.55) | 5.25 |
| Thyroid gland (193) | 10 | 1.14 | (0.55–2.10) | 0.58 | 4 | 3.04 | (0.83–7.79) | 7.83 | 9 | 3.43 | (1.57–8.62) | 9.82 |
| Other non-smoking-related cancers | 324 | 0.79 | (0.71–0.88) | −39.77 | 60 | 0.92 | (0.70–1.18) | −15.63 | 129 | 1.04 | (0.87–1.24) | 7.98 |
Abbreviations: CI=confidence interval; ICD=International Classification of Disease; Obs=observed number; PY=person-years.
Smoking-related cancers included: head and neck (ICD-9: lip: 140, tongue: 141, mouth: 143–145, oropharynx: 146, hypopharynx: 148, pharynx unspecified: 149, and larynx: 161), salivary gland (142), nasopharynx (147), oesophagus (150), nose and nasal cavity (160), stomach (151), liver (155), and pancreas (157), bladder and kidney (188 189), leukaemia (204–208).
AER is expressed as per 100 000.