Table 1.
The presence of an HBS correlates with transcriptional upregulation but not with repression by hypoxia
| HBS+ |
HBS− |
P-value | ||||
|---|---|---|---|---|---|---|
| Obsr. | Expc. | Obsr. | Expc. | |||
| Upregulated | 145 | 88 | 113 | 170 | 3.18 × 10−14 | |
| Nonregulated | 3766 | 3823 | 7459 | 7402 | ||
| Downregulated | 69 | 64 | 121 | 126 | 0.42 | |
| Nonregulated | 3766 | 3771 | 7459 | 7454 | ||
Genes were classified as upregulated [mean log2(hypoxia/normoxia) > 0 and P < 0.01], downregulated [mean log2(hypoxia/normoxia) < 0 and P < 0.01] or nonregulated (P > 0.01).
The number of genes in each group with at least one potential HBS (HBS+) or none (HBS−) is shown (Obsr.).
The number of genes expected by chance in each group is also shown (Expc.).
The significance of the difference between the observed versus expected frequencies was calculated by a Chi-squared test and the resulting P-value is shown (P-value).