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. 2010 Jan 6;38(7):2229–2246. doi: 10.1093/nar/gkp1214

Figure 2.

Figure 2.

Identification of HERV-W loci specifically up-regulated in testicular tumor. (A) Structure and genomic position of the identified HERV-W loci. For all the identified loci, the HERV genomic structures are detailed: U3, R and U5 are the functional regions of the LTRs; gag, pol and env are the proviral genes; and Δenv indicates that the envelope gene is deleted. The family type of 5′ and 3′ parts of the HW13386 chimeric locus are indicated. (B) Fold change between normal and tumoral counterpart. Differential RNA expression between normal and tumoral counterpart is indicated for each tissue (testis, uterus, prostate, lung, breast, ovary and colon) for the six overexpressed loci (HW08822, HW13386, HW22795, HW33438, HW38223 and ERVWE1/Wenv). The RNA samples were similar to those used in the microarray experiments. The qRT-PCR results were normalized with G6PD housekeeping gene expression, which had an averaged copy number of 1000.