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. 2010 Jan 13;38(7):2498–2511. doi: 10.1093/nar/gkp1225

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — (A) Structures of ANA and 2′F-ANA in comparison with DNA and RNA. (B) Numbering scheme of the 10-mer hybrid duplexes used for this study. X indicates the DNA, 2′F-ANA or ANA strand. The corresponding hybrids are named DR, FR and AR, respectively. Thymines are replaced by uracils in the ANA strand. (Use of T instead of U does explain some of the increased duplex stability of the 2′F-ANA-containing hybrid. However, comparison of 2′F-ANA and ANA-containing hybrids where neither strand includes T/U and studies where both 2′F-ANA and ANA contained T confirm that the 2′F-ANA-containing hybrids are still significantly more stable than their ANA-containing counterparts.) (6,7).