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. 2010 Jan 13;38(7):2498–2511. doi: 10.1093/nar/gkp1225

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Details of X2′–H8 interactions in FR and AR. Left, the structure of the FR duplex, showing distances between F2′ and aromatic H6/H8 protons. These distances correlate well with cross-peak intensity of the ¹⁹F – ¹H HOESY spectra shown in Figure 3. Right, the same region of the AR duplex showing unfavorable steric interactions with 2′-OH.