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AptTFIIB-4 and its derivatives. (A) Predicted secondary structure of AptTFIIB-4. The structure was generated by mfold and supported by mutational analysis. The box indicates the ‘B4’ aptamer moiety. (B) Standardized aptamer B4 and its derivatives. The ‘S’ and ‘L’ loops are indicated in B4. The boxes indicate the identical GC-clamp in each structure.
