Fig. 2.
Exhaled NO profiles and best-fit model simulations for 4 representative children with asthma. NO was collected at 3 exhalation flows (50, 100, and 200 ml/s) from 20 children with mild asthma. Exhaled NO in the phase III region of each flow is plotted as a function of the number of exhaled airway volumes (Vex/Vaw; thin trace). Multicompartment model best-fit curves are represented by a thick black line, and 2-compartment model best-fit curves are represented by dashed lines. A: subject 6 has elevated FeNO (>25 ppb at a flow of 50 ml/s) with an average normalized phase III slope of −1.4%. Multicompartment and 2-compartment model best fits are nearly identical. B: subject 10 has elevated FeNO, with an average normalized phase III slope of −2.2%. C: subject 12 has low FeNO, with an average normalized slope of 0.2%. Multicompartment and 2-compartment model best fits are nearly identical. D: subject 18 has low FeNO, with a normalized phase III slope of −2.7%.