Fig. 1.
Goats hypoventilate and have reduced sensitivity to CO2 for at least 7 days after carotid body denervation (CBD), but thereafter, there is a normalization of breathing. Depicted are data from a single, awake goat and on each day data were obtained while breathing room air (initial point) and while inhaling in order 3, 5, and 7% CO2 gas mixtures. Note the reduced ventilation and increased arterial Pco2 (PaCO2) in eupnea and the reduced ventilatory response slope over the first 7 days after CBD. Data are from Ref. 45. V̇i, inspired pulmonary ventilation.