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. Author manuscript; available in PMC: 2010 Apr 12.
Published in final edited form as: ACS Chem Biol. 2009 Jan 16;4(1):41–52. doi: 10.1021/cb8002607

Figure 1.

Figure 1

a–b) Arrangement of the PKS portions of the pikromycin and erythromycin biosynthetic pathways and their macrolactone products. c–d) Two examples of the intermodular transfer and elongation assays featuring the erythromycin PKS system (19–22). Abbreviations: ACP, acyl carrier protein, AT – acyltransferase, DH – dehydratase, ER – enoyl reductase, KR – ketoreductase, KS – ketosynthase, KSQ – decarboxylative ketosynthase, TE – thioesterase. Docking domains are colored by proposed subclass; H1–T1 are red, and H2–T2 is gold. Domain sizes are not drawn to scale.