Table I.
Intestinal Transit Times in Npc+/+ or +/−, Npc1−/− and GFAP-Npc1, Npc1−/− mice
GFAP-Npc1, Npc1−/− |
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---|---|---|---|---|
Genotype | Npc1+/+ or +/− | Npc1−/− | □ 100 days | □ 100 days |
Transit time without fasting | (4) 192.5 ± 27.3† | (3) 296.7 ± 37.9* | (3) 202.7 ± 13.7 | (3) 331.7 ± 47.3** |
Transit time with fasting | (4) 111.9 ± 5.9 | (3) 144.2 ± 2.2* | (2) 111.8 ± 1.3 | ND |
% body weight consumed during study |
(4) 4.3 ± 0.5 | (3) 6.05 ± 0.44†† | (2) 4.3 ± 0.75 | ND |
(n) ave. ± std. error
p □ 0.01 vs. Npc1+/+ or +/−
p □ 0.01 vs. □ 100 days
p □ 0.05 vs. Npc1+/+ or +/−
ND not determined