Table II.

Number of Ganglion Cells in the Myenteric and Submucosal Plexus of Npc1^+/+, Npc1^−/−, and GFAP-Npc1, Npc1^−/− mice

	GANGLION CELLS PER CIRCUMFERENCE
	Myenteric Plexus			Submucosal Plexus
	Distal Ileum	Proximal Colon	Rectum	Proximal Codon
Npc1 +/+	55 ± 24†	106 ± 21	53 ± 27	23.5 ± 7.2
Npc1 −/−	55 ±24′	103 ± 3	47 ± 7	18.6 ± 7.0
GFAP-Npc1, Npc1−/−	50 ± 29	100 ± 30	34 ±11	15.5 ± 7.9

^†mean ± std. dev.; none of the differences between genotypes were significant (Student T Test; p>0.05); 3 animals per group. Calculations based on the observed standard deviations and sample sizes indicate that differences in mean values greater than 38% must be present for a 90% likelihood of statistical significance (power = 90%).

The average numbers per circumference of bowel (used as the denominator to control for distension) are expressed in the table.