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. 2010 Jan 27;103(4):1748–1757. doi: 10.1152/jn.00949.2009

Table 2.

Impact of paraoxon, carbachol, and nicotine

Frequency, Hz Peak Amplitude, pA
A. Muscarinic Receptors
Baseline (4) 1.27 ± 0.17 14.61 ± 2.62
Atropine 1.072 ± 0.23 14.74 ± 2.47
Atropine + carbachol 1.19 ± 0.33 14.51 ± 0.85
Baseline (5) 0.54 ± 0.14 13.85 ± 1.22
Atropine 0.46 ± 0.17 13.62 ± 1.62
Atropine + paraoxon 0.55 ± 0.20 14.79 ± 1.44
Baseline (4) 0.91 ± 0.14 13.70 ± 2.21
Carbachol 1.49 ± 0.43* 17.76 ± 1.69
Carbachol + atropine 1.15 ± 0.48 15.45 ± 1.08
Baseline (4) 1.18 ± 0.32 13.77 ± 1.60
Paraoxon 1.84 ± 0.60* 15.01 ± 2.03*
Paraoxon + atropine 1.21 ± 0.36 14.69 ± 1.57
B. Nicotinic receptors
Baseline (5) 1.01 ± 0.34 18.63 ± 1.93
α-bungarotoxin 1.17 ± 0.22 15.65 ± 3.08
α-bungarotoxin + nicotine 1.28 ± 0.32 15.68 ± 2.84
Baseline (4) 1.21 ± 0.16 12.049 ± 0.09
α-bungarotoxin 1.31 ± 0.18 12.04 ± 0.10
α-bungarotoxin + paraoxon 1.69 ± 0.15* 11.88 ± 0.10
Baseline (n = 5) 1.49 ± 0.38 14.59 ± 2.74
Nicotine 1.73 ± 0.42* 15.55 ± 2.76*
Nicotine + α-bungarotoxin 1.51 ± 0.45 14.75 ± 1.74
Baseline (4) 1.59 ± 0.19 11.31 ± 0.09
Paraoxon 2.36 ± 0.33** 12.08 ± 0.27*
Paraoxon + α-bungarotoxin 2.28 ± 0.30* 12.24 ± 0.42*

The impact of the cholinergic agonists paraoxon, carbachol, and nicotine coapplied with antagonists before and after application of antagonists of muscarinic or nicotinic receptors on sEPSXC frequency and amplitude.

*

P < 0.05;

**

P < 0.005 using repeated measures ANOVA test.