Fig. 5.

Effect of meloxicam on AQP2 expression in fluid-restricted and fluid-loaded rats. A and C: representative immunoblots. B and D: summary of all data. In fluid-restricted animals, the cyclooxygenase (COX)-2-selective NSAID meloxicam caused a significant decrease in AQP2 expression closely comparable to the results with the nonselective ibuprofen and indomethacin. In contrast, meloxicam had no significant effect in fluid-loaded animals, suggesting that there is little COX-2 activity under these conditions. *P < 0.05 with respect to control.