Table 1.
Baseline Period, days | Baseline Water Intake, ml/day | Drug Dose, mg·kg−1·day−1 | Treatment Period, days | Treatment Water Intake, ml/day | |
---|---|---|---|---|---|
Indomethacin | 2 | Free access | 8 | 2 | Free access |
Ibu | 2 | Free access | 40 | 2 | Free access |
Ibu/dehydration | 2 | Free access | 40 | 2 | 0 (control, free access) |
Ibu/FR | 2 | 20 | 40 | 2 | 20 |
Ibu/FL | 2 | 50 | 40 | 2 | 50 |
Mel/FR | 2 | 20 | 1 | 2 | 20 |
Mel/FL | 2 | 50 | 1 | 2 | 50 |
Mel/FL/FR | 2 | 50 | 1 | 4 | 20 |
Ibu, ibuprofen; Mel, meloxicam; FL, fluid loaded; FR, fluid restricted.