Table 2.
Effects of ibuprofen treatment and mild dehydration on diuresis, urine osmolality, and excretion of salt and PGE
| Number of Days of Treatment | Fluid-Restricted Control | Fluid-Restricted Ibuprofen | P Value | |
|---|---|---|---|---|
| Urine output, ml/day | 1 | 7.5 ± 0.6 | 9.8 ± 0.9 | <0.05 |
| 2 | 9.0 ± 0.7 | 10.8 ± 0.9 | 0.14 | |
| Urine osmolality, mosmol/kgH2O | 1 | 2,235 ± 119 | 1,763 ± 125 | <0.02 |
| 2 | 2,117 ± 98 | 1,637 ± 79 | <0.003 | |
| Sodium, mmol/day | 1 | 1.3 ± 0.1 | 1.8 ± 0.2 | 0.07 |
| 2 | 1.8 ± 0.2 | 1.8 ± 0.1 | 0.93 | |
| Potassium, mmol/day | 1 | 3.4 ± 0.3 | 4.2 ± 0.3 | 0.08 |
| 2 | 4.4 ± 0.5 | 3.9 ± 0.2 | 0.30 | |
| Chloride, mmol/day | 1 | 1.7 ± 0.1 | 1.8 ± 0.1 | 0.56 |
| 2 | 1.9 ± 0.2 | 1.9 ± 0.2 | 0.92 | |
| PGE, ng/day | 1 | 5.6 ± 0.5 | 5.4 ± 0.7 | 0.82 |
| 2 | 5.8 ± 1.3 | 5.4 ± 0.8 | 0.80 |
Values are means ± SE.