Table 3.

Effects of fluid loading and ibuprofen treatment on diuresis, osmolality, and excretion of salt and PGE

	Number of Days of Treatment	Fluid-Loaded Control	Fluid-Loaded Ibuprofen	P Value
Urine output, ml/day	1	29.7 ± 2	29.3 ± 1.1	0.93
	2	27.5 ± 1.8	26.7 ± 1.6	0.86
Urine osmolality, mosmol/kgH2O	1	566 ± 25	556 ± 19	0.78
	2	524 ± 16	517 ± 9	0.92
Sodium, mmol/day	1	0.7 ± 0.2	0.7 ± 0.1	0.99
	2	0.8 ± 0.2	0.8 ± 0.1	0.85
Potassium, mmol/day	1	2.7 ± 0.3	2.2 ± 0.1	0.16
	2	2.2 ± 0.2	2.2 ± 0.1	0.90
Chloride, mmol/day	1	1.7 ± 0.2	1.6 ± 0.03	0.61
	2	1.7 ± 0.2	1.5 ± 0.1	0.65
PGE, ng/day	1	11.1 ± 2.2	9.4 ± 2.0	0.58
	2	10.8 ± 2.0	9.5 ± 1.9	0.67

Values are means ± SE.