Table 4.

Effect of water restriction and meloxicam treatment on diuresis, urine osmolality, and excretion of salt and PGE

	Number of Days of Treatment	Fluid-Restricted Control	Fluid-Restricted Meloxicam	P Value
Urine output, ml/day	0	6.3 ± 0.5	6.5 ± 0.7	0.76
	1	6.3 ± 0.8	6.0 ± 0.9	0.84
	2	5.6 ± 0.5	5.8 ± 0.5	0.86
Urine osmolality, mosmol/kgH2O	0	2,470 ± 125	2,470 ± 276	1.00
	1	2,604 ± 174	2,621 ± 384	0.97
	2	2,977 ± 137	2,611 ± 145	0.21
Sodium, mmol/day	1	1.3 ± 0.1	1.3 ± 0.08	0.68
	2	1.4 ± 0.1	1.4 ± 0.1	0.77
Potassium, mmol/day	1	2.8 ± 0.1	2.5 ± 0.1	0.18
	2	3.2 ± 0.3	2.7 ± 0.1	0.12
Chloride, mmol/day	1	1.8 ± 0.1	1.6 ± 0.1	0.23
	2	1.8 ± 0.2	1.8 ± 0.1	0.84
PGE, ng/day	1	18.0 ± 4.8	20.1 ± 4.5	0.67
	2	30.6 ± 6.4	25.8 ± 4.7	0.54

Values are means ± SE.