Table 5.

Effect of meloxicam and mild over-hydration on diuresis, osmolality, and excretion of salt and PGE

	Number of Days of Treatment	Fluid-Loaded Control	Fluid-Loaded Meloxicam	P Value
Urine output, ml/day	0	30 ± 1.2	29 ± 1.2	0.72
	1	28 ± 1.8	25 ± 1.9	0.44
	2	29 ± 1.4	31 ± 1.8	0.27
Urine osmolality, mosmol/kgH2O	0	578 ± 20	579 ± 24	0.97
	1	631 ± 27	608 ± 29	0.57
	2	600 ± 22	533 ± 13	0.02
Sodium, mmol/day	1	1.0 ± 0.1	1.0 ± 0.1	0.96
	2	1.1 ± 0.1	1.3 ± 0.1	0.21
Potassium, mmol/day	1	2.6 ± 0.1	2.2 ± 0.2	0.08
	2	2.5 ± 0.1	2.6 ± 0.2	0.70
Chloride, mmol/day	1	1.7 ± 0.1	1.4 ± 0.1	<0.05
	2	1.6 ± 0.1	1.6 ± 0.1	0.98
PGE, ng/day	1	7.2 ± 0.5	4.8 ± 0.6	<0.01
	2	6.4 ± 1.0	5.7 ± 1.0	0.61

Values are means ± SE.