Table 6.

Effects of meloxicam under fluid-controlled conditions on diuresis, osmolality, and excretion of salt and PGE

	Number of Days of Treatment	Fluid-Loaded, Fluid-Restricted Control	Fluid-Loaded, Fluid-Restricted Meloxicam	P Value
Urine output, ml/day	1	9.5 ± 0.64	9.5 ± 1.04	1.0
	2	7.25 ± 0.75	5.0 ± 1.0	0.12
	3	10 ± 0.91	8.25 ± 1.93	0.44
	4	11.25 ± 0.63	8.75 ± 1.6	0.20
Osmolality, mosmol/kgH2O	1	1,963 ± 78.6	1,892 ± 69.5	0.51
	2	2,309 ± 156.7	2,043 ± 142.2	0.23
	3	1,937.5 ± 100.7	1,910 ± 112.3	0.86
	4	1,909 ± 85.4	1,954.5 ± 134.7	0.78
Sodium, mmol/day	1	1.3 ± 0.1	1.6 ± 0.2	0.32
	2	1.2 ± 0.2	1.3 ± 0.1	0.73
	3	1.4 ± 0.3	1.5 ± 0.2	0.76
	4	1.4 ± 0.2	1.6 ± 0.1	0.32
Chloride, mmol/day	1	1.5 ± 0.1	1.6 ± 0.1	0.90
	2	1.3 ± 0.1	1.5 ± 0.1	0.19
	3	1.6 ± 0.2	1.6 ± 0.1	0.89
	4	1.6 ± 0.2	1.7 ± 0.1	0.55
Potassium, mmol/day	1	2.7 ± 0.3	2.6 ± 0.3	0.71
	2	2.7 ± 0.3	2.7 ± 0.1	0.85
	3	3.1 ± 0.5	3.3 ± 0.3	0.82
	4	3.0 ± 0.3	3.4 ± 0.3	0.32
PGE, ng/day	1	20.0 ± 2.3	24.4 ± 1.7	0.14
	2	25.5 ± 3.0	28.8 ± 2.4	0.41
	3	24.4 ± 2.7	27.9 ± 1.7	0.29
	4	26.5 ± 4.0	28.7 ± 3.2	0.69

Values are means ± SE.