Table 2.

Pathways that significantly (P value <0.05) differed at 26 days between jck and wild-type genotypes based on a functional score analysis

Pathway	#Metabolites	#Sig.	#Up	#Down	#Sig. Up	#Sig. Down	P Value
Pentose phosphate pathway	4	2	3	1	1	1	0.001
Glucosinolate biosynthesis	4	2	0	4	0	2	0.002
Amino, sugar, and nucleotide sugar metabolism	7	3	6	1	2	1	0.008
Purine metabolism	9	2	7	2	2	0	0.010
Pentose and glucuronate interconversions	7	2	6	1	2	0	0.011
Galactose metabolism	8	3	4	4	1	2	0.016
Tryptophan metabolism	5	2	0	5	0	2	0.032

Only pathways containing at least 3 metabolites are shown. #Metabolites is the number of metabolites identified through gas chromatography/mass spectometry in each pathway; #Sig is the number of metabolites that differed significantly (permutation P value <0.05) based on a permutation t-test; #Up and #Down are the number of metabolites up- and downregulated, respectively, in the jck genotype; #Sig. Up and #Sig. Down are the number of metabolites significantly up- and downregulated, respectively, based on P values from permutation t-tests. P values were calculated from a permutation null distribution based on 10,000 permutations.