Table 1.
Simulation 1: CD inflow concentrations and resulting urine flow and content
| Urine |
||||||||
|---|---|---|---|---|---|---|---|---|
| CD Inflow* |
Flow rate† |
|||||||
| Stage | Na+, mM | Urea, mM | nl/min | ml/day | Total osmolality, mosmol/kgH2O | Na+, mM | Urea, mM | NaCl+Urea, mosmol/kgH2O |
| 1 | 0.0‡ | 750.8 | 0.0581 | 6.36 | 2,075 | 116.1 | 1,605 | 1,770 |
| 2 | 39.58 | 675.7 | 0.0492 | 5.38 | 2,094 | 129.6 | 1,543 | 1,736 |
| 3 | 79.16 | 600.7 | 0.0447 | 4.89 | 2,031 | 141.2 | 1,419 | 1,636 |
| 4 | 118.7 | 525.6 | 0.0451 | 4.94 | 1,881 | 156.0 | 1,239 | 1,489 |
| 5 | 158.3 | 450.5 | 0.0524 | 5.73 | 1,655 | 181.7 | 1,013 | 1,317 |
| 6 | 197.9 | 375.4 | 0.0681 | 7.45 | 1,404 | 215.0 | 772 | 1,144 |
| 7 | 237.5 | 300.3 | 0.0907 | 9.93 | 1,186 | 246.4 | 554.0 | 990.8 |
| 8 | 277.1 | 225.2 | 0.117 | 12.8 | 1,018 | 273.5 | 375.7 | 867.7 |
| 9 | 316.7 | 150.2 | 0.145 | 15.9 | 893.3 | 279.3 | 231.3 | 738.3 |
| 10 | 356.2 | 75.08 | 0.173 | 18.9 | 798.3 | 319.4 | 111.5 | 695.9 |
| 11 | 395.8 | 0.0 | 0.199 | 21.8 | 725.5 | 341.1 | 9.2 | 636.5 |
*
At each stage, nonreabsorbable (NR) solute is present in collecting duct (CD) inflow at a concentration of 20 mM.
†
Urine flow rate is given in nl·min−1·nephron−1 and in ml·day−1·animal−1.
‡
Although a 0 NaCl content is likely unphysiological, this inflow condition is provided for comparison with the other stages.