Table 2.
Parameters varied in simulation 2
| Parameter | Stage 1 | Stage 2 | Stage 3 | Stage 4 | Stage 5 | Stage 6 | Stage 7 | Stage 8 | Stage 9 | Stage 10 | Stage 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CD inflow rate, percent change* | 10% | 10% | 15% | 25% | 15% | 5% | −5% | −15% | −25% | −20% | −10% |
| Boundary tubular fluid osmolality, percent change* | +1% | +3% | +5% | +10% | +25% | +35% | +40% | +45% | +50% | +30% | 0% |
| Initial CD Pf, ×10−5 cm/s | 460 | 460 | 460 | 460 | 460 | 460 | 300 | 400 | 400 | 200 | 200 |
| CD PNa, ×10−5 cm/s | 0.5 | 0.5 | 0.5 | 0.5 | 0.75 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| IM depth where CD Purea changes, (xCD), mm | 2.25 | 2.25 | 2.00 | 1.75 | 1.75 | 1.75 | 1.50 | 1.50 | 1.50 | 1.75 | 2.25 |
| CD Purea exponential growth rate | 9.0 | 7.5 | 6.0 | 3.0 | 3.0 | 2.0 | 2.0 | 2.0 | 1.0 | 3.0 | 9.0 |
| CD Na+ Vmax, percent change* | −30% | −40% | −40% | −30% | −10% | 0% | +10% | +10% | +10% | +10% | 0% |
Pf, PNa, Purea, water permeability, sodium permeability, urea permeability, respectively; Vmax, maximum transport rate; IM, inner medulla.
*
Relative to base-case value.