Table 1.
Parameter | Wild-Type | NOS 3−/− |
---|---|---|
24 h water intake, ml | 1.8 ± 0.4 | 1.6 ± 0.2 |
24 h urine excretion, ml | 2.1 ± 0.2 | 2.2 ± 0.3 |
Body weight, g | 24.3 ± 0.7 | 23.8 ± 0.8 |
1% sucrose intake, ml/h | 1.1 ± 0.1 | 1.2 ± 0.1 |
MAP before load, mmHg | 108 ± 4 | 121 ± 3* |
MAP after load, mmHg | 110 ± 2 | 118 ± 3* |
Heart rate after load, beats/min | 543 ± 10 | 562 ± 8 |
Plasma Na+, mEq/l, after load | 156 ± 1 | 155 ± 1 |
Plasma vasopressin after load, pg/ml | 5 ± 1 | 7 ± 3 |
PRC after load, ng ANG I•ml−1•h−1 | 364 ± 51 | 377 ± 41 |
Plasma creatinine after load, μg/ml | 2.0 ± 0.2 | 2.4 ± 0.2 |
GFR during first 30 min after load, ml/min | 2.0 ± 0.4 | 1.6 ± 0.4 |
Values are presented as means ± SE. MAP, mean arterial pressure; NOS 3, nitric oxide synthase 3; PRC, plasma renin concentration; GFR, glomerular filtration rate.
P ≤ 0.05 vs. wild-type mice.