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. 2010 Feb 10;298(4):R1050–R1055. doi: 10.1152/ajpregu.00181.2009

Table 1.

Characteristics of experimental animals (NOS 3 −/− mice and their wild-type controls)

Parameter Wild-Type NOS 3−/−
24 h water intake, ml 1.8 ± 0.4 1.6 ± 0.2
24 h urine excretion, ml 2.1 ± 0.2 2.2 ± 0.3
Body weight, g 24.3 ± 0.7 23.8 ± 0.8
1% sucrose intake, ml/h 1.1 ± 0.1 1.2 ± 0.1
MAP before load, mmHg 108 ± 4 121 ± 3*
MAP after load, mmHg 110 ± 2 118 ± 3*
Heart rate after load, beats/min 543 ± 10 562 ± 8
Plasma Na+, mEq/l, after load 156 ± 1 155 ± 1
Plasma vasopressin after load, pg/ml 5 ± 1 7 ± 3
PRC after load, ng ANG I•ml−1•h−1 364 ± 51 377 ± 41
Plasma creatinine after load, μg/ml 2.0 ± 0.2 2.4 ± 0.2
GFR during first 30 min after load, ml/min 2.0 ± 0.4 1.6 ± 0.4

Values are presented as means ± SE. MAP, mean arterial pressure; NOS 3, nitric oxide synthase 3; PRC, plasma renin concentration; GFR, glomerular filtration rate.

*

P ≤ 0.05 vs. wild-type mice.