. 2010 Jan 27;298(4):R1111–R1116. doi: 10.1152/ajpregu.00803.2009

Table 1.

Physiological variables and body and organ weights in adult male, castrated male, and female offspring of rats fed either a normal or protein-restricted diet during pregnancy

	Normal Protein			Low Protein
	Males	CAS	Females	Males	CAS	Females
n	8	8	8	9	9	8
Weaning weight, g	57 ± 4	56 ± 3	50 ± 3	56 ± 1	56 ± 1	53 ± 1
Body weight at study, g	489 ± 15	412 ± 13^*	274 ± 10^*^†	441 ± 10^‡	398 ± 14^*	263 ± 5^*^†
Total kidney weight, g	3.31 ± 0.15	2.35 ± 0.08^*	1.81 ± 0.04^*^†	3.20 ± 0.08	2.32 ± 0.06^*	1.89 ± 0.04^*^†
Kidney/body wt, %	0.684 ± 0.019	0.576 ± 0.013^*	0.677 ± 0.022^†	0.736 ± 0.012^‡	0.581 ± 0.010^*	0.725 ± 0.011^†^‡
GFR/KW, ml·min⁻¹·g⁻¹	0.97 ± 0.05	1.14 ± 0.03	1.35 ± 0.11^*	1.04 ± 0.06	1.23 ± 0.05	1.21 ± 0.07
ERPF/KW, ml·min⁻¹·g⁻¹	3.29 ± 0.31	3.79 ± 0.13	4.41 ± 0.32^*	3.61 ± 0.21	4.08 ± 0.11	4.29 ± 0.26
GFR/BW, ml·min⁻¹·100 g⁻¹	0.649 ± 0.022	0.653 ± 0.021	0.893 ± 0.069^*^†	0.751 ± 0.049	0.718 ± 0.032	0.863 ± 0.042
ERPF/BW, ml·min⁻¹·100 g⁻¹	2.20 ± 0.16	2.17 ± 0.10	2.89 ± 0.13^*^†	2.61 ± 0.17^‡	2.41 ± 0.10	3.07 ± 0.15^†
Hematocrit	0.48 ± 0.01	0.47 ± 0.01	0.43 ± 0.01^*	0.48 ± 0.01	0.45 ± 0.02	0.44 ± 0.01^*
Plasma protein, g/dl	6.9 ± 0.1	7.1 ± 0.1	6.6 ± 0.1	6.9 ± 0.1	7.1 ± 0.1	6.6 ± 0.2^†
Urine protein excretion, mg/day	21 ± 3	16 ± 3	3 ± 1^*^†	27 ± 5	14 ± 3^*	4 ± 1^*
Adrenal weight, g	0.070 ± 0.004	0.074 ± 0.004	0.062 ± 0.004^†	0.067 ± 0.002	0.072 ± 0.003	0.061 ± 0.003
Adrenal/body weight, %	0.014 ± 0.001	0.018 ± 0.001^*	0.023 ± 0.001^*^†	0.016 ± 0.001	0.018 ± 0.001	0.023 ± 0.001^*^†
Heart weight, g	1.617 ± 0.066	1.365 ± 0.051^*	0.984 ± 0.027^*^†	1.456 ± 0.055^‡	1.317 ± 0.037	1.001 ± 0.043^*^†
Heart/body weight, %	0.335 ± 0.009	0.335 ± 0.013	0.366 ± 0.008	0.334 ± 0.008	0.331 ± 0.011	0.384 ± 0.013^*^†
Plasma renin activity, ng AI·ml⁻¹·h⁻¹	4.29 ± 0.38	5.18 ± 0.65	6.15 ± 0.57	4.82 ± 0.79	4.96 ± 0.49	7.40 ± 0.91^*^†
Testosterone, ng/ml	2.29 ± 0.42	0.35 ± 0.08^*	0.61 ± 0.07^*	1.80 ± 0.21	0.33 ± 0.09^*	0.61 ± 0.04^*
RVR, mmHg·ml⁻¹·min	6.60 ± 0.51	7.97 ± 0.36	9.01 ± 0.60^*	6.35 ± 0.40	7.83 ± 0.29	8.74 ± 0.45^*
RVR/KW, mmHg·ml⁻¹·min·g⁻¹	2.01 ± 0.17	3.43 ± 0.20^*	4.97 ± 0.33^*^†	2.03 ± 0.16	3.39 ± 0.18^*	4.64 ± 0.25^*^†

Values are means ± SE; n, no. of rats. CAS, castrated; GFR, glomerular filtration rate; KW, kidney weight; ERPF, effective renal plasma flow; BW, body weight; AI, angiotensin I; RVR, renal vascular resistance. P < 0.05 compared with

value for intact males,

^†

value for CAS males,

^‡

normal protein animals of same sex group.