Fig. 6.

A: quantitation of EETs in the perfusate collected from shear stress (2 and 10 dyn/cm²)-stimulated mesenteric arteries of female eNOS-KO mice in control conditions (n/n = 5/9) and transfected with RXRγ siRNA (n/n = 5/6) or nonsilencing siRNA (n/n = 5/5) for 72 h, respectively. *P < 0.05 compared with control. B: shear stress (10 dyn/cm²)-induced vasodilation in control conditions (n/n = 5/9) (day 1) and after transfection with RXRγ (n/n = 5/5) or nonsilencing siRNA (n/n = 4/5) for 72 h (day 4). *P < 0.05 compared with nonsilencing siRNA. C and D: original (C) and summarized data (D, 3 blots) for RXRγ, CYP2C29, and Akt protein expression of vessels in control conditions and transfected with RXRγ siRNA. *P < 0.05 compared with control.