. 2010 May;51(5):1035–1048. doi: 10.1194/jlr.M002378

TABLE 2.

Obesity phenotypes in fasted mice sacrificed at 140 ± 14 days

Lipc Locus	Transgene^c	Sex	N	BW (g)	AN (cm)	FWAT (g)	GWAT (g)	RWAT (g)	MWAT (g)	AI^d
B6/B6	—	M	12	23.9 ± 0.63^a	9.79 ± 0.09	0.165 ± 0.02^a	0.301 ± 0.03^a	0.048 ± 0.01^a	0.075 ± 0.01	2.44 ± 0.22^a
B6/B6	+	M	13	24.5 ± 0.68^a,b	9.75 ± 0.08	0.135 ± 0.01^a	0.268 ± 0.03^a	0.040 ± 0.01^a	0.119 ± 0.05	2.25 ± 0.28^a
129/129	—	M	21	26.1 ± 0.56^b	9.80 ± 0.06	0.262 ± 0.03^b	0.596 ± 0.05^b	0.117 ± 0.02^b	0.191 ± 0.03	4.39 ± 0.33^b
129/129	+	M	12	24.9 ± 0.79^a,b	9.75 ± 0.09	0.233 ± 0.03^b	0.516 ± 0.08^b	0.108 ± 0.02^b	0.115 ± 0.02	3.78 ± 0.38^b
Overall P	Lipc Locus			NS	NS	0.001	<0.0001	<0.0001	NS	<0.0001
	Transgene			NS	NS	NS	NS	NS	NS	NS
	Interaction			NS	NS	NS	NS	NS	NS	NS
B6/B6	—	F	16	19.13 ± 0.59^a	9.38 ± 0.08	0.118 ± 0.01^a	0.151 ± 0.01^a	0.016 ± 0.00^a	0.048 ± 0.01^a	1.73 ± 0.09^a
B6/B6	+	F	12	20.39 ± 0.80^a,b	9.51 ± 0.08	0.123 ± 0.01^a	0.174 ± 0.03^a	0.024 ± 0.01^a	0.048 ± 0.01^a	1.78 ± 0.15^a
129/129	—	F	23	20.92 ± 0.33^b	9.46 ± 0.07	0.256 ± 0.0^b	0.332 ± 0.03^b	0.063 ± 0.01^b	0.131 ± 0.02^b	3.63 ± 0.23^b
129/129	+	F	8	21.47 ± 0.48^b	9.64 ± 0.12	0.248 ± 0.02^b	0.406 ± 0.03^b	0.060 ± 0.01^b	0.156 ± 0.02^b	4.03 ± 0.26^b
Overall P	Lipc Locus			0.020	NS	<0.0001	<0.0001	0.001	<0.0001	<0.0001
	Transgene			NS	NS	NS	NS	NS	NS	NS
	Interaction			NS	NS	NS	NS	NS	NS	NS

AI, adipose index; AN, anal-nasal length; BW, live fasted body weight; FWAT, femoral white adipose tissue; GWAT, gonadal white adipose tissue; MWAT, mesenteric white adipose tissue; NS, not significant; RWAT, retroperitoneal white adipose tissue; SPRET, SPRET/EiJ. All animals are ≥N10. HL^−/−,+S and HL^−/− are littermates, and HL^+/+,+S and HL^+/+ are littermates. Data shown are means ± SEM. Values not sharing a superscript (^a,b) are different by P < 0.05 by Sidak's t-test for multiple comparisons.

SPRET/EiJ hepatic ipase

(Sum of four white adipose depots/BW) × 100