TABLE 4.
Plasma cholesterol levels in nonfasted mice sacrificed at 140 ± 14 days
| Genotype | Sex | N | TC (mg/dl) | CM-C (mg/dl) | VLDL-C (mg/dl) | LDL-C (mg/dl) | HDL-C (mg/dl) |
|---|---|---|---|---|---|---|---|
| HL−/− | M | 5 | 109.90 ± 2.5a | 0.454 ± 0.1 | 3.71 ± 0.4a | 7.91 ± 0.3a | 97.82 ± 2.4a |
| HL+/+ | M | 4 | 79.87 ± 0.8b | 0.658 ± 0.2 | 4.95 ± 0.6a | 9.51 ± 0.4b | 64.74 ± 0.8b |
| HL−/−,+S | M | 4 | 55.21 ± 2.4c | 0.250 ± 0.0 | 2.38 ± 0.2b | 4.19 ± 0.2c | 48.39 ± 0.2c |
| Overall P | <0.0001 | NS | 0.008 | <0.0001 | <0.0001 |
CM-C, chylomicron-cholesterol; HDL-C, HDL-cholesterol; LDL-C, LDL-cholesterol; TC, total cholesterol; VLDL-C, VLDL-cholesterol. All animals are ≥N10. HL−/− and HL−/−,+S mice are littermates. HL+/+ mice are from a backcross between N10 HL+/+,+S and HL+/+ mice. Data presented are means ± SEM. Analyses were run on natural log transformed data. For posthoc analysis, sexes were analyzed separately. Values not sharing superscript (a,b,c) are different by Scheffe's posthoc test (P < 0.05).