TABLE 5.
Plasma triglyceride levels in fasted mice sacrificed at 140 ± 14 days
| Genotype | Sex | N | Total TG (mg/dl) | CM-TG (mg/dl) | VLDL-TG (mg/dl) | LDL-TG (mg/dl) | HDL-TG (mg/dl) |
|---|---|---|---|---|---|---|---|
| HL−/− | M | 6 | 27.4 ± 4.0a,b | 1.2 ± 0.2 | 12.4 ± 2.4b | 10.1 ± 1.5a | 3.7 ± 0.4a |
| HL+/+ | M | 8 | 50.5 ± 6.3a | 1.7 ± 0.3 | 30.9 ± 4.3a | 15.3 ± 1.6b | 2.6 ± 0.4a |
| HL−/−,+S | M | 7 | 22.2 ± 4.0b | 1.1 ± 0.2 | 11.4 ± 3.1b | 8.4 ± 0.5a | 1.3 ± 0.2b |
| HL+/+,+S | M | 5 | 30.8 ± 2.8a,b | 1.2 ± 0.3 | 9.6 ± 1.3b | 18.1 ± 1.1b | 1.8 ± 0.3a,b |
| HL−/− | F | 6 | 24.6 ± 4.0 | 1.0 ± 0.3a | 9.8 ± 2.1a | 9.6 ± 1.2 | 4.2 ± 0.5a |
| HL+/+ | F | 5 | 19.1 ± 1.1 | 0.42 ± 0.3a,b | 5.1 ± 0.8a,b | 12.9 ± 0.8 | 0.73 ± 0.1b |
| HL−/−,+S | F | 4 | 18.8 ± 1.6 | 0.68 ± 0.3a,b | 8.3 ± 0.9a | 8.5 ± 0.5 | 1.4 ± 0.2b |
| HL+/+,+S | F | 5 | 16.1 ± 1.6 | 0.10 ± 0.0b | 3.3 ± 0.7b | 12.1 ± 1.1 | 0.59 ± 0.1c |
| Overall P | |||||||
| HL | 0.018 | 0.022 | 0.003 | <0.0001 | <0.0001 | ||
| Sex | <0.0001 | <0.0001 | <0.0001 | NS | <0.0001 | ||
| HL x Sex | 0.007 | 0.004 | <0.0001 | NS | <0.0001 |
CM-TG, chylomicron-triglyceride; HDL-TG, HDL-triglyceride; LDL-TG, LDL-triglyceride; TG = triglyceride; VLDL-TG = VLDL-triglyceride. HL−/− and HL−/−,+S are N5 and N6 littermates. HL+/+ mice are from a parental cross. HL+/+,+S mice are from a backcross between N10 HL+/+,+S and HL+/+ mice. Data presented are means ± SEM. Analyses were run on natural log transformed data. For posthoc analysis, sexes were analyzed separately. Values not sharing superscript (a,b,c) are different by Scheffe's posthoc test (P < 0.05).