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. 2010 May;51(5):1057–1062. doi: 10.1194/jlr.M002915

TABLE 3.

Percentage change in lipid parameters after 13 weeks of treatment

Change from baseline lipid parameter (%) Placebo (N = 11) Mipomersen (N = 10)
LDL-C 1.0 ± 16.5 −22.0 ± 17.8a
VLDL-C −3.1 ± 24.8 −13.2 ± 13.8
Non-HDL-C 0.4 ± 16.3 −21.3 ± 16.6b
HDL-C 7.5 ± 12.7 4.0 ± 9.2
TC 1.9 ± 14.9 −16.4 ± 13.4a
TG −7 (−45.9–42.3)c −16.3 (−35.1–9.8)c
Apo A1 2.2 ± 12.0 −1.3 ± 8.6
Apo B 5.7 ± 13.1 −19.9 ± 17.4d
Lp(a) 8.0 ± 16.1 −19.6 ± 14.9d

Data was analyzed at week 15. Data are presented as the mean ± standard deviation. Apo, apolipoprotein; HDL-C, HDL-cholesterol; LDL-C, LDL-cholesterol; LP(a), lipoprotein (a); TC, total cholesterol TG, triglycerides; VLDL-C, VLDL-cholesterol.

a

P < 0.01 compared with placebo using the Exact Wilcoxon Rank sum test.

b

P < 0.05 compared with placebo using the Exact Wilcoxon Rank sum test.

c

Data are presented as the median (min–max).

d

P < 0.001 compared with placebo using the Exact Wilcoxon Rank sum test.