TABLE 1.
Changes in body weight, liver- to body weight ratio, and liver toxicity
| Diagnostic Marker | Control |
CA-Fed |
||
|---|---|---|---|---|
| Wild-Type Mice | Fxr-Null mice | Wild-Type Mice | Fxr-Null Mice | |
| BW (%) | 101.5 ± 2.7 | 102.7 ± 1.6 | 90.7 ± 8.9 | 73.3 ± 4.16b |
| LW/BW ratio | 3.92 ± 0.21 | 3.79 ± 0.12 | 3.61 ± 0.45 | 5.08 ± 0.46b |
| ALT (IU/l) | 71.7 ± 20.1 | 141.4 ± 62.8a | 1240 ± 1110 | 1810 ± 625 |
| ALP (IU/l) | 163 ± 18.2 | 221 ± 102 | 165 ± 58.0 | 456 ± 91.0b |
Comparison of diagnostic markers between wild-type and Fxr-null mice in either control or cholic acid-treated groups (n = 4–12). Values are means ± SD. ALP, alkaline phosphatase; ALT, alanine aminotransferase; BW, body weight; FXR, farnesoid X receptor; LW, liver weight.
a
P < 0.01 compared with wild-type mice.
b
P < 0.001 compared with wild-type mice.