TABLE 1.

Summary of the effects of sPLA₂-III, AA, PA, LPC, MβCD, benzyl alcohol (C₆H₅OH), and Pluronic F68 (PF68) on membrane fluidity, accumulation of APP at the cell surface, and secretion of sAPP_α and Aβ

Cell Treatment	Membrane Fluidity	APP at Cell Surface	Secretion of sAPPα	Aβ
sPLA2-III	↑	↑	↑	↓
AA	↑	↑	↑	NC
LPC	NC	NC	NC	NC
PA	NC	NC	NC	NC
MβCD	↑a	↑a	↑a	↓ab
C6H5OH	↑c	NA	↑c	↓c
PF68	↓c	NA	↓c	↑c

↑ Denotes increase, ↓ denotes decrease, and NC denotes no change. MβCD, methyl-β-cyclodextrin.

^aResults obtained from Kojro et al. (21).

^bAβ_1-40.

^cResults obtained from Peters et al. (66).