. Author manuscript; available in PMC: 2010 Apr 12.

Published in final edited form as: Nat Rev Drug Discov. 2008 Mar;7(3):221–230. doi: 10.1038/nrd2519

Table 3.

Loci and variants exhibiting association with type 2 diabetes mellitus in GWA studies

T2DM phenotype	Locus	Variants (rs)	Refs
Susceptibility	TCF2	4430796, 7501939	78
	TCF7L2	4506565, 7903146, 7901695	18,54–57,63
	PPARG	1801282	55,63
	KCNJ11	5219, 5212	54,55,63
	SLC30A8	13266634, rs118253964	55,56,63
	HHEX	1111875	55,63
	IGF2BP2	4402960	54,55,63
	CDKAL1	9456871, 7754840, 10946398, 7756992	18,55,57,63
	CDKN2A/B	10811661, 564398	54,55,63
	Chromosome 11, intergenic	9300039	55
	FTO	9939609, 7193144, 8050136	18,55,63
Low-density lipoprotein	APOE	4420638	54
High-density lipoprotein	CETP	1800775	54
High-triglyceride level	LPL	17482753	54
High-triglyceride level	GCKR	780094	54

Above variants are associated P <5 × 10⁻⁷. T2DM, type 2 diabetes mellitus.