Table 3.
Dopamine turnover in each part of the brain.
| Brain region | Group | Turnover | |||
|---|---|---|---|---|---|
| DOPAC/dopamine | 3-MT/dopamine | HVA/dopamine | (DOPAC+HVA)/dopamine | ||
| Striatum | Control | 0.076 ± 0.004 | 0.077 ± 0.004 | 0.121 ± 0.004 | 0.197 ± 0.006 |
| Exposed | 0.064 ± 0.002* | 0.071 ± 0.003 | 0.098 ± 0.004* | 0.162 ± 0.005** | |
| Hippocampus | Control | -- | 0.60 ± 0.14 | 24.66 ± 12.22 | -- |
| Exposed | -- | 0.51 ± 0.06 | 5.15 ± 0.64 | -- | |
| Midbrain | Control | 0.61 ± 0.05 | 0.20 ± 0.03 | 0.99 ± 0.13 | 1.601 ± 0.165 |
| Exposed | 0.55 ± 0.03 | 0.17 ± 0.01 | 0.86 ± 0.06 | 1.404 ± 0.079 | |
| Cerebellum | Control | -- | -- | 17.22 ± 5.55 | -- |
| Exposed | -- | -- | 39.49 ± 13.83 | -- | |
| Brainstem | Control | 3.22 ± 0.13 | -- | 0.16 ± 0.01 | 3.38 ± 0.13 |
| Exposed | 3.25 ± 0.09 | -- | 0.35 ± 0.04 | 3.60 ± 0.07 | |
Data are presented as mean ± SEM (n = 10 per group). The statistical significance is shown as *P < 0.05, **P < 0.01; ND, not detectable. Abbreviations: DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; 3-MT, 3-methoxytyramine.