Table 1.
Detailed description of each component of the transmission function
| Component of transmission function | Description |
|---|---|
| Ptrans(Ii, Is) | Probability of disease transmission from infected to susceptible individual. |
| β | Disease transmission coefficient, chosen to achieve baseline epidemics with specific R0 values. |
| Susc(Is) | Age specific susceptibility of infectee or susceptible individual. |
| Inft(Ii) | Infectiousness of infector as a function of time since infection and symptomatic status. |
| AVF(Ii, Is) | Antiviral factor which reduces transmission probability when antiviral based interventions are applied to individuals Ii, Is or both. |
| The following different situations may arise when we model antiviral effectiveness. | |
| AVF(Ii, Is) = 1 - AVEi | if the infected individual is treated with antiviral drugs and no antiviral prophylaxis is applied to the susceptible individual |
| AVF(Ii, Is) = 1 - AVEs | if antiviral prophylaxis are applied to the susceptible individual and no antiviral treatment is used with the infected individual |
| AVF(Ii, Is) = (1-AVEi)*(1-AVEs) | if both infected and susceptible individuals are receiving antiviral drugs for treatment and prophylaxis respectively |
| AVF(Ii, Is) = 1 | if neither infector nor susceptible individuals are receiving antiviral drugs |