Table 1.
The DCP Effects Model (DCP-EM) was derived from the stepwise regression of the DCP dose versus: serum Tryptophan, Kynurenine, Kyn/Trp; HBV DNA [Southern], HBV DNA [PCR], HBV RNA [PCR], HBe antigen [ELISA]; Average # Liver HBcAg Nuclei per Total, Average # Liver HBcAg Cytoplasms per Total, Average # Liver HBcAg Nuclei per Quarter Field; IL-1a, IL-1b, IL-2, IL-3, IL-4, IL-6, IL-9, IL-10, IL-12, MCP-1, TNF-α, MIP-1, GM-CSF, RANTES, and liver IL-6; log HBV DNA [Southern], log rel. HBV DNA [PCR], log HBV RNA [PCR], and log HBe antigen [ELISA].
| Coefficients of variables in cluster modelling DCP dosing effects | ||||
|---|---|---|---|---|
| Unstandardized Coefficients | Standardized Coefficients | |||
| DCP-EM Model* (variable cluster) | B | Std. Error | Beta | Sig. |
| (Constant) | 26.309 | 4.976 | .000 | |
| MCP-1 | -.022 | .007 | -.371 | .003 |
| Log HBV DNA (PCR) | -4.065 | 1.376 | -.359 | .005 |
| Kyn/Trp | -.560 | .196 | -.349 | .006 |
| GM-CSF | .070 | .030 | .283 | .023 |
Probability-to-Enter = .10 and Probability-to-Remove = .15. The model is significant to *p = .001.
Derived DCP-EM Regression Model*:
DCP-EM score = 26.309 - 0.22 [MCP-1 rel. pg/ml] - 4.065 [Log rel. HBV DNA (PCR)]
-.560 [Kyn/Trp uM/mM] + 0.070 [GM-CSF rel. pg/ml]