Table 2.
List of anticorrelated genes
| SCO ID | Definition | Pathway | r |
|---|---|---|---|
| SCO2286 | alkaline phosphatase | folate biosynthesis | --0.80 |
| SCO3249 | [acyl-carrier-protein] S-malonyltransferase | fatty acid biosynthesis | --0.78 |
| SCO5887 | [acyl-carrier-protein] S-malonyltransferase | fatty acid biosynthesis | --0.75 |
| SCO0386 | asparagine synthetase (glutamine-hydrolysing) | aspartate metabolism | --0.75 |
| SCO3248 | pentadecanoyl-[acyl-carrier protein] synthesis | fatty acid biosynthesis | --0.74 |
| SCO5886 | pentadecanoyl-[acyl-carrier protein] synthesis | fatty acid biosynthesis | --0.71 |
| SCO5888 | pentadecanoyl-[acyl-carrier protein] synthesis | fatty acid biosynthesis | --0.70 |
| SCO0828 | alkaline phosphatase | folate biosynthesis | --0.67 |
| SCO2068 | alkaline phosphatase | folate biosynthesis | --0.66 |
| SCO3246 | pentadecanoyl-[acyl-carrier protein] synthesis | fatty acid biosynthesis | --0.63 |
| SCO3595 | D-alanine-D-alanine ligase | D-alanine metabolism | --0.63 |
| SCO3221 | prephenate dehydrogenase | tryptophan biosynthesis | --0.63 |
| SCO6655 | GTP cyclohydrolase II | riboflavin metabolism | --0.61 |
| SCO6787 | butyryl-CoA dehydrogenase | propanoate metabolism | --0.59 |
| SCO2687 | GTP cyclohydrolase II | riboflavin metabolism | --0.52 |
The most strongly anticorrelated genes are listed on the basis of correlation between gene expression and predicted flux (r < --0.25). Pathway annotations are based on the KEGG database without manual curation. Most of the genes belong to the pink or red cluster and are upregulated in stationary phase; these represent potential new genes involved in antibiotics biosynthesis. Several examples validating this interpretation are discussed in detail in the text.